Mechanism of ActionĬholecalciferol gets generated in the skin upon sun exposure.

Īside from its known role in bone mineral metabolism, various studies have found a link between cholecalciferol supplementation and favorable prognoses of different diseases such as hypertension, type 1 and 2 diabetes, cardiovascular disease, cancer, rheumatoid arthritis (RA), polycystic ovarian syndrome (POS), multiple sclerosis (MS), systemic lupus erythematosus (SLE), and various dermatologic diseases. The off-label indications for cholecalciferol include hypothyroidism, prevention of osteoporosis, and Vitamin D insufficiency/ deficiency in both healthy patients or those with chronic kidney disease (CKD). The labeled indication for cholecalciferol is dietary supplementation. During winter and in areas with minimal sun exposure, dietary supplementation is necessary for optimal musculoskeletal health. Its primary function is to maintain normal calcium and phosphate levels in the serum.

Outline the importance of collaboration and coordination among the interprofessional team to enhance patient care when dosing and monitoring cholecalciferol to improve patient outcomes.Ĭholecalciferol, also known as vitamin D3, is a secosteroid produced by the skin and can also be present in certain foods such as dairy products, eggs, and fish.

Summarize appropriate monitoring/potential toxicity of cholecalciferol.

Identify the indications for using exogenous supplementation of cholecalciferol.

Describe the mechanism of action of cholecalciferol.This activity will highlight the mechanism of action, adverse event profile, and other vital factors such as off-label uses, dosing, pharmacodynamics, monitoring, and relevant interactions pertinent for healthcare team members in the management of patients with vitamin D deficiency/ insufficiency and related conditions. This activity reviews the indications, action, and contraindications for cholecalciferol as a valuable agent in managing vitamin D deficiency/insufficiency and other disorders when applicable. Cholecalciferol is a medication used to manage and treat osteoporosis and Vitamin D insufficiency/ deficiency in both healthy patients and those with chronic kidney disease (CKD).

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